Onii-chan Asa made Zutto Gyutte Shite

The main character Sora suffered from severe asthma and his four younger sisters-Sarah, Akane, Kohaku and Sumi took turns every day to sleep with him to monitor his condition. Years passed and she was now ready to explore romance with the help of Onii chan and their close relationship ends so well with lot of sex after she gives her virginity to him.